{"id":6205,"date":"2022-04-04T14:14:04","date_gmt":"2022-04-04T14:14:04","guid":{"rendered":"https:\/\/wilate.shinedezign.pro\/ca\/?page_id=6205"},"modified":"2023-01-23T15:17:03","modified_gmt":"2023-01-23T15:17:03","slug":"on-demand","status":"publish","type":"page","link":"https:\/\/wilate.shinedezign.pro\/ca\/on-demand\/","title":{"rendered":"On-demand"},"content":{"rendered":"\t\t
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<\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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On-demand treatment<\/span><\/h1>

People with von Willebrand disease may require on-demand treatment for bleeding, including nosebleeds, prolonged bleeding from minor cuts, bleeding during dental treatment, and heavy menstrual bleeding.1<\/sup><\/strong><\/p>


<\/sup><\/strong>The efficacy of wilate\u00ae<\/sup><\/span> for on-demand treatment of bleeds has been demonstrated in clinical trials in adults and children with all von Willebrand disease types and is supported by data from real-world studies.2, 5<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Need for effective on-demand treatment<\/span><\/h2>\n

in von Willebrand disease6, 7<\/sup><\/span><\/em><\/h3>\n

People with von Willebrand disease can be susceptible to spontaneous and traumatic bleeding, including<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The efficacy of wilate\u00ae<\/sup><\/span><\/h2>

for on-demand treatment of bleeds has been demonstrated in clinical trials in adults and children with all types of von Willebrand disease2*<\/sup><\/span><\/em><\/h3>

Data from four prospective, Phase II and III trials **<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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* Indication: Prevention and treatment of haemorrhage or surgical bleeding in von Willebrand disease, when desmopressin treatment alone is ineffective or contra-indicated.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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The efficacy of wilate\u00ae<\/sup><\/span><\/h2>

for on-demand treatment of bleeds has been demonstrated in clinical trials in adults and children with all types of von Willebrand disease2<\/sup><\/em><\/h3>

Data from four prospective, Phase II and III trials<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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wilate\u00ae<\/sup><\/span> efficacy rated \u2018excellent\u2019<\/span> or \u2018good\u2019<\/span><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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of 1095 treated<\/span> bleeding events<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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The efficacy of wilate\u00ae<\/sup><\/span><\/h2>

for on-demand treatment of bleeds has been demonstrated in clinical trials in adults and children with all types of von Willebrand disease2<\/sup><\/span><\/em><\/h3>

Data from four prospective, Phase II and III trials<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The efficacy of wilate\u00ae<\/sup><\/span><\/h2>

for on-demand treatment of bleeds is supported by data from real-world studies<\/em><\/h3>

WIL-20: Non-interventional Phase IV study3<\/sup><\/p>

WIL-20 included 111 patients (aged 1 to 83 years) at 31 centres. 29 patients were treated on-demand with wilate\u00ae<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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wilate\u00ae<\/sup><\/span> efficacy rated \u2018excellent\u2019<\/span> or \u2018good\u2019<\/span> in<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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of 127 treated bleeding<\/span> events<\/span> in 25 patients*<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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*as rated by the investigator.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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The efficacy of wilate\u00ae<\/sup><\/span><\/h2>\n

for on-demand treatment of bleeds is supported by data from real-world studies<\/span><\/em><\/h3>\n

Real-world retrospective studies<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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wilate\u00ae<\/sup><\/span> efficacy rated \u2018excellent\u2019<\/span> or \u2018good\u2019<\/span> in<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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25 adults<\/span>
(median age 42 years, range 19\u201382 years)4<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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of 46<\/span> bleeding events<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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15 adolescents and children<\/span> (median age 7 years,\nrange 0\u201317 years)5<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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of 44<\/span> bleeding events<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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References<\/h4>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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  1. de Wee EM et al. Thromb Haemost<\/em> 2012; 108:683-92.<\/li>
  2. Berntorp E et al. Haemophilia<\/em> 2009; 15:122-30.<\/li>
  3. Sholzberg M et al. TH Open<\/em> 2021; 5:e264-72.<\/li>
  4. Batty P et al. Haemophilia<\/em> 2014; 20:846-53.<\/li>
  5. Khair K et al. Haemophilia<\/em> 2015; 21:e44-50.<\/li>
  6. Lillicrap D and James P. WFH Treatment of Hemophilia 2009; No. 47 (available at http:\/\/www1.wfh.org\/publication\/files\/pdf-1204.pdf<\/a>).<\/li>
  7. Castaman G et al. Haematologica<\/em> 2013; 98:667-74.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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    Surgical prophylaxis with wilate\u00ae<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    \n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tPrepare for surgery<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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    Prevention of bleeding with wilate\u00ae<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    \n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tProphylaxis<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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    Use of wilate\u00ae\u00a0<\/sup> in people with von Willebrand disease\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    \n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tTolerability<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    On-demand treatment People with von Willebrand disease may require on-demand treatment for bleeding, including nosebleeds, prolonged bleeding from minor cuts, bleeding during dental treatment, and heavy menstrual bleeding.1 The efficacy of wilate\u00ae for on-demand treatment of bleeds has been demonstrated in clinical trials in adults and children with all von Willebrand disease types and is […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-6205","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nOn demand treatment of von willebrand disease<\/title>\n<meta name=\"description\" content=\"People with vwd may require on-demand treatment for prolonged nose bleeding, bleeding during dental treatment, heavy menstrual bleeding.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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